Yeah, some of the things I've quickly realised with my first profile are:
1) auto-pilot buttons get out of sync (I have AP on/off states in my profile)
2) buttons you never realised would need to be on the same tab...do actually need to be on the same tab to stop you constantly switching
3) You think its a good idea to map all controls to TB profile....its not, some commands should stay on the HOTAS, and TB should be the 'less used' or 'can never remember the key' or 'i dont need that button in a hurry' or 'i dont use that button too often'.
My new golden rule is if I need it often, it gets mapped to the HOTAS, if not, it goes in TB profile - I only got TB this week and have only done one profile. I'm gonna post that up on the forums soon but I expect to do a new/revised profile now that I've had a chance to use it in "anger" on the 504 Air to Ground server
Anyways, thats what I've learnt.