I really wish I could drop the "sendto" options, its a legacy thing from before I knew what I was doing
The sendto options only really make sense now for GUI based applications, so you can swap between active windows. The "sendto" option makes the send_macro routine look for the window name, *makes it active or got focus*, and then sends the keys. Great for GUI apps on your desktop, but a bit useless for games to be honest.
To be honest, while playing a game, there is no need to be using the sendto option. TB will just send the macros blindly, and if the game is active, then it will receive the macros.
I would highly recommend that you drop the sendto options in any profile (for games) and just let TB send the keypresses.